Bioengineering: The nervous system
Objective: The course introduces the central nervous system from an engineering perspective. This is a core course in the curriculum of undergraduate and Masters students at Hopkins Biomedical Engineering.
Course Director: Reza Shadmehr
Assistants: Julia Choi (jchoi AT bme.jhu.edu),
Meeting Times: MWF 4:00-5:00 PM, Hodson 210
1. Tuesday, February 06, 2007
2. Tuesday, February 20, 2007
3. Tuesday, March 06, 2007
4. Tuesday, March 27, 2007
5. Tuesday, April 10, 2007
6. Tuesday, April 24, 2007
Lecture 1. Reza Shadmehr
Lecture 2. Reza Shadmehr
Principle of contralateral control; study of language; perception of color, motion, and faces; memory and amnesia; left and right cerebral hemispheres.
Lecture 3. Reza Shadmehr
Neurons and glia, properties of action potentials, neurotransmitters, second messengers, memory via synaptic plasticity and long-term potentiation, neuronal turnover in the brain, brain imaging.
Recording from the nervous system; examples from the olfactory system; examples of plasticity from the electric fish.
Synaptic membrane dynamics; construction of action potentials via the HH model; Calcium dependent potassium channels; bursting; T calcium channels.
Synaptic transmission; synaptic vesicle hypothesis; post-synaptic receptors; model of ionotropic effects; strength of a synapse; threshold and refractoriness; temporal summation of EPSPs.
Short and long pathways of metabotropic mechanisms; G-proteins.
Location of synaptic terminals on a neuron; cable model of neuron morphology; derivation of the cable equation; cable equation parameters; solutions for a semi-infinite cable.
Lecture 10. Alfredo Kirkwood
Cellular mechanisms of learning (1). slides
Lecture 11. Alfredo Kirkwood
Cellular mechanisms of learning (2). slides
Sensory systems: sensation, perception, psychophysics. slides
Modality, location, timing of a stimulus; sensory modality and labeled line; spatial distribution of stimulus; intensity of stimulus; psychophysical laws governing perception
Audition, vision, proprioception. slides
Auditory receptors: inner ear, basilar membrane, hair cells; Visual receptors: retina, rods and cones, color vision; Somatic receptors: mechanoreceptors, spatial discrimination receptive fields
Properties of spike trains. slides
Spike trains and measurement of neuronal response; average discharge rate; temporal coding; neural firing as Poisson processes
Concept of receptive field. slides
RF for visual and auditory inputs; size varies with sensory area; RF may have both inhibitory and excitatory components
Transformation of neural codes from PNS to CNS. slides
Pathways for sensory system in vision, audition, and proprioception; sensory regions of the cerebral cortex; topographic maps in the sensory system of the cortex; increase in complexity of neuronal properties; cortical columns; vision for localization vs. identification
Neural plasticity in the cortex. slides
Broadmann’s designation of cortical areas in humans; sensory inputs and development; modification of cortical maps due to experience; illusions; perception and neural activity; damage to the cortex and effect on behavior
Neuroengineering: decoding the brain. slides
Lecture 19. Larry Schramm
Lecture 20. Kechen Zhang
Integrate and fire models; perceptrons and feedforward networks; exclusive or problem; multi-layer perceptrons;
Lecture 21. Kechen Zhang
Supervised learning; Hebb’s learning rule; LTP in the hippocampus.
Lecture 22. Kechen Zhang
Hopfield network and associative memory; energy functions; short-term memory networks;
Lecture 23. Kechen Zhang
Attractors, waves, oscillations, and synchrony
Lecture 24. Kechen Zhang
Lecture 25. Kechen Zhang
Lecture 26. Kechen Zhang
Lecture 28. Ed Conner
Central visual pathways
Lecture 29. Reza Shadmehr
Lecture 30. Reza Shadmehr
Motor neurons; muscle length-tension properties; motor units; muscle’s sensory system; control of posture
Lecture 31. Reza Shadmehr
Fatigue, spike triggered averaging, spindles and golgi tendon organs; delay in feedback control; loss of proprioception; functional electrical stimulation.
Lecture 32. Reza Shadmehr
Visual pathways to the cortex; descending tracts from the brain; split brain patients; role of brainstem centers in control of posture; encoding of visual scene by neurons in the visual cortex; gain fields.
Lecture 33. Reza Shadmehr
Computations involved in reaching; prism adaptation; disorders of parietal cortex; neglect.
Lecture 34. Reza Shadmehr
Motor cortex and somatotopic maps, change in the motor maps due to injury and plasticity; control of movements by the motor cortex; translation of movement plans into action.
Lecture 35. Amy Bastian
Lecture 36. Tissue engineering of neurons and axonal regeneration.
Lecture 37. Tissue engineering of neurons.