Jay joined the lab in 2018 as an PhD student in the BME program, after receiving a BS in Mechanical Engineering, as well as a BS in Neurobiology, both with the highest honors from the University of Texas, Austin. He had a wide range of undergraduate research experiences, from studying the effects of viral infections on drug metabolism to the manufacturing design of mechanical systems.
Jay wrote the entire behavioral software system that we use in training our marmosets. He then recorded activities of neurons in the cerebellar cortex during a task in which the subjects experienced an error, but had the option of either correcting that error, or simply observe it and withhold their correction. He discovered that the climbing fiber input to the cerebellum encoded both the direction of a random sensory event, as well as the direction of a forthcoming voluntary movement. Surprisingly, these two kinds of information were transmiteed to different Purkinje cells. His work suggests that cerebellar neurons that learn from different teachers (climbing fibers) contribute to different aspects of behavior.
E Sedaghat-Nejad, JS Pi, P Hage, MA Fakharian, R Shadmehr (2022) Synchronous spiking of cerebellar Purkinje cells during control of movements. Proceedings of the National Academy of Sciences 119 (14), e2118954119.
E Sedaghat-Nejad, MA Fakharian, J Pi, P Hage, Y Kojima, R Soetedjo, S Ohmae, JF Medina, and R Shadmehr(2021) Journal of Neurophysiology 126 (4), 1055-1075.
Muller, Salomon Zev, Jay S. Pi, Paul Hage, Mohammad Amin Fakharian, Ehsan Sedaghat-Nejad, and Reza Shadmehr. "Complex spikes perturb movements, revealing the sensorimotor map of Purkinje cells." Current Biology, 2023.
Hage, Paul, In Kyu Jang, Vivian Looi, Mohammad Amin Fakharian, Simon P. Orozco, Jay S. Pi, Ehsan Sedaghat-Nejad, and Reza Shadmehr. "Effort cost of harvest affects decisions and movement vigor of marmosets during foraging." eLife, 2023.
Publications
Publications
Jay Pi
Jay Pi